Work

Involvement of ryanodine receptors in the contraction of small pulmonary veins

Year: 2025

Type: article

Abstract: The results indicate that RyR2 would be the most relevant isoform in SPV contraction induced by depolarization, whereas RyR1 and RyR3 would participate in the contractile mechanism induced by GqPCR agonists. It is worth noting that based on the scRNA seq studies, RyR1 was shown to be the less expressed isoform in SMCs in the rat lung, which indicates that RyR2 and RyR3 may be the most relevant isoforms participating in the contraction of SPV.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00375.2024

Authors: Francisca Varas, Marcelo Fonseca, Natalia Astudillo, Damian Gorski, Danielle Harrison, Carol San Martin, Santiago Ramirez, Mauricio Henriquez

Institutions: University of Chile, The University of Texas Health Science Center at Houston, Hospital Clínico de la Universidad de Chile

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Universidad de Chile, Agencia Nacional de Investigación y Desarrollo, Fondo Nacional de Desarrollo Científico y Tecnológico

Awards: G2613469267, ROLE OF VITAMIN D RECEPTOR POLYMORPHISMS ON A? PEPTIDE CLEARANCE IN MILD COGNITIVE IMPAIRMENT OF THE ALZHEIMER TYPE, G8564435758, G931062048

OpenAlex ID: W4409162344

FWCI: 0.261

Cites: 54

Cited by: 1

Related to: 10