Year: 2025
Type: article
Abstract: 5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 499]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [478, 394]).
Authors: Rodrigo Andrade, Patrick P. A. Humphrey, Klaus Peter Latté, Luc Maroteaux, Graeme R. Martin, Derek N. Middlemiss, Ewan Mylecharane, John Neumaier, Stephen J. Peroutka, John A. Peters, Bryan Roth, Pramod R. Saxena, Trevor Sharp, Andrew Sleight, Carlos M. Villalon, Daniel Hoyer, Rebecca Hills, Katharine Herrick-Davis, Nicholas M. Barnes, Gordon Baxter, Joel Bockaert, Theresa Branchek, Amy Butler, Marlene L. Cohen, Aline Dumuis, Richard M. Eglen, Manfred Göthert, Mark Hamblin, Michel Hamon, Paul R. Hartig, René Hen, Julie Hensler, Frank Yocca
Institutions: Wayne State University, University of Cambridge, Sorbonne Université, GlaxoSmithKline (United Kingdom), The University of Sydney, University of Washington, University of Dundee, Erasmus University Rotterdam, University of Oxford, Roche (Switzerland), Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, The University of Melbourne, University of Edinburgh, Albany Medical College, University of Birmingham, Eli Lilly (United States), Université de Montpellier, PerkinElmer (United States), University of Bonn, Columbia University, Bristol-Myers Squibb (United States)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409162557