Work

Atypical hemolytic uremic syndrome: a case report and review of thrombotic mechanisms

Year: 2025

Type: article

Abstract: Using specific clinical analyses, including genetic, hemolytic, blood, and disease manifestations, leads to a unique hypothesis about our patient’s atypical hemolytic uremic syndrome pathophysiology. Notably, a novel C3 defect, in addition to a common factor B mutation, leads to doubt over current theories of alternative complement overactivation and further drives focus onto the thrombotic nature of the disease. We propose a pathology of defective platelet-leukocyte-endothelial adhesions, leading to poor leukocyte extravasation.

Source: Journal of Rare Diseases

DOI: 10.1007/s44162-025-00072-3

Author: George N. Zsidisin

Institutions: Carol Davila University of Medicine and Pharmacy, Institutul Clinic Fundeni

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409162886