Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Our study aimed to investigate the effects of chromosomal aberrations and genetic mutations of elderly individuals diagnosed with AML and determine its prognostic significance. Methods We retrospectively collected data over nearly 7 years from our hospital, encompassing 90 cases of elderly AML patients. Baseline information of patients was gathered and followed up, and statistical analysis was conducted using SPSS 25.0. Results Among the 90 elderly non-M3 AML patients, 56 (62.2%) exhibited multiple gene mutations, with 9 (10%) patients displaying five or more gene mutations. The incidence of NPM1 mutation was significantly higher in patients with normal karyotypes compared to those with abnormal karyotypes (P = 0.001). Patients with FLT3, ASXL1, or TP53 mutations displayed lower rates of CR compared to wild-type counterparts. Kaplan-Meier analysis revealed that TET2 mutation (P = 0.0474), FLT3-ITD mutation (P = 0.0364), TP53 mutation (P = 0.0031), and 17p abnormality (P = 0.00285) were predictive of shorter OS. TP53 mutations (P = 0.0440), 17p abnormalities (P = 0.0272), 7q abnormalities (P = 0.0174), and complex karyotypes (P = 0.0447) were associated with shorter RFS. Conclusion Our findings suggest that elderly AML patients exhibit distinctive genetic profiles, and favorable prognosis genes do not seem to apply to elderly AML patients.
Source: Frontiers in Genetics
Authors: Zhe Chen, Lina Ding, Jieni Yu, Jing Jin, Zhijian Zhang, Jiaping Fu, Pan Hong, Leihua Fu
Institution: Shaoxing People's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409163887