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Assessment of the Therapeutic and Protective Effects of Fermented Ripe and Unripe Carica papaya Fruit Extracts on Histomorphological and Biochemical Alterations in Ibuprofen-Induced Esophageal Ulceration in Wistar Rats

Year: 2024

Type: article

Abstract: The objective of this paper is to assess the therapeutic and protective effects of fermented ripe and unripe Carica papaya fruit extracts on histomorphological and biochemical alterations in ibuprofen-induced esophageal ulceration in wistar rats usin appropriate standard methods. Results revealed decrease in body weight compared to Control. Similarly, there was significant organ weight reduction. Biochemical analysis revealed that C. papaya fruit extracts significantly increased (p<0.05) the levels of SOD and catalase, and significantly decreased (p<0.05) in MDA level. Histological analysis showed normal structural arrangement, with hyperkeratosis and squamous hyperplasia in the control group. Ibuprofen treated group demonstrated severe squamous dysplasia, while pretreatment FRP and FUP groups, showed mild squamous dysplasia while the omeprazole group exhibited moderate squamous dysplasia. Ibuprofen when administered alone or accompanied by other drugs caused some form of gastroesophageal ulcerations which were ameliorated by the administration of fermented C. papaya fruit extracts.

Source: Journal of applied science and environmental management

DOI: 10.4314/jasem.v28i12.7

Authors: M. A. Amadi, V. C. Ezeuko, I. Onyeleonu, B. A. Monday, D. K. Ogbuokiri, A. E. Akpotu, O. C. Ogbe, M. A. Olugbenga, B. T. Fubara

Institutions: PAMO University of Medical Sciences, University of Benin, Nnamdi Azikiwe University, Ambrose Alli University

Language: English

Topic: Papaya Research and Applications

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409164736

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