Simultaneous coherent–incoherent motion imaging in brain parenchyma
Year: 2025
Type: article
Abstract: A phase-sensitive diffusion tensor magnetic resonance imaging (MRI) sequence is proposed with pulse timing optimization scheme to achieve velocity resolution of less than 20 μm s −1 and an integrated image reconstruction and velocity map generation pipeline. The application of ultra-slow flow relevant to neurofluids is enabled by the use of a recently developed, ultra-high-performance brain MRI gradient system. By simultaneously reconstructing magnitude and phase data, both metrics that characterize diffusive fluid motion and coherent velocity maps are calculated non-invasively in human subjects, time-resolved over the entire cardiac cycle. The resulting acquisition and reconstruction of velocity maps in brain parenchyma, enabled by high-performance brain imaging systems, promises to be an important approach to investigating ultra-slow neurofluid flow and glymphatic circulation.
Source: Interface Focus
Authors: Isabelle Heukensfeldt Jansen, Nastaren Abad, Afis Ajala, Chitresh Bhushan, J. Kent Werner, J. Kevin DeMarco, H. Douglas Morris, Angeliki Pollatou, Gail Kohls, Haymanot Yalewayker, Samrawit Yalewayker, Maureen Hood, Sonja Skeete, Elizabeth Metzger, Vincent B. Ho, Thomas K. F. Foo, Luca Marinelli
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4409173585