The Bidirectional and Temporal Associations of Depression With Allergic Rhinitis and Chronic Rhinosinusitis: A Nationwide Cross-Sectional Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: This study aimed to delve into the bidirectional and temporal relationship between depression, allergic rhinitis (AR) and chronic rhinosinusitis (CRS).Methods: A total of 17,028 participants from the Korean National Health and Nutritional Examination Survey, surveyed in 2016, 2018, and 2020, were included in this study.Participants' medical histories were used to determine their depression, AR and CRS status, as well as the age at diagnosis.Logistic regression analyses were conducted to reveal the associations between AR/CRS and depression.Subgroup analysis was performed considering various clinical characteristics.Results: Regardless of occurring independently or coexisting, AR and CRS consistently preceded the diagnosis of depression.The prevalence of depression was higher among patients with AR and CRS, and similarly, the prevalence of AR and CRS was elevated among patients with depression (all P < 0.001).Depression was associated with increased odds of AR (odds ratio [OR], 1.646; 95% confidence interval [CI], 1.309-2.071;P < 0.001) and CRS (OR, 1.882; 95% CI, 1.427-2.416;P < 0.001).Similarly, AR (OR, 1.613; 95% CI, 1.278-2.036;P < 0.001) and CRS (OR, 1.869; 95% CI, 1.415-2.467;P < 0.001) were both associated with heightened odds of depression. Conclusions:The study findings indicated a bidirectional and complex association between depression and AR/CRS, emphasizing the importance of early detection and intervention.
Authors: Han Chen, Lin Wang, Jisheng Zhang, Xudong Yan, Longgang Yu, Yan Jiang
Institutions: Qingdao University, Affiliated Hospital of Qingdao University
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G1510466441, G4797742211, G7222233301
OpenAlex ID: W4409175503