Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the impact of aging in different skin layers on the formation of wrinkles and sagging. METHODS: In a single-center clinical study, the skin micromorphology, wrinkles, and sagging of 34 participants aged 42-60 years who use an antiaging product for 56 days are discussed retrospectively and observationally. The variation trend of each parameter and the correlation between micromorphology parameters and wrinkles and sagging are analyzed. RESULTS: Parameters related to epidermal aging show a strong correlation with wrinkles and sagging, whereas parameters related to dermal aging show no significant correlation with wrinkles and sagging; in addition, parameters related to the dermal-epidermal junction (DEJ) show a moderate correlation with wrinkles and sagging. CONCLUSION: For individuals in the rapid and stable aging phases, aging of the epidermis has a greater impact on wrinkles and sagging than aging of the dermis and DEJ.
Source: Journal of Biophotonics
DOI: 10.1002/jbio.70028
Authors: Dangdang Cheng, Qin Zhang, Wanwen Shan, Feifei Wang
Institution: Yunnan Botanee Biotechnology Group Co.
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409175819