Work

Recent Advances in the Formation and Transformation of Propargyl Radical

Year: 2025

Type: article

Abstract: Propargyl radical is a very important free radical in organic synthesis. The tautomerization with the allenyl radical enables the diverse reactivities, and then, propargyl compounds and allenes can be obtained. Because of its properties, how to control the chemical selectivity and enantioselectivity is the key in the radical propargyl functionalization. In this review, the reactions involving propargyl radicals in recent years are summarized according to the means for the production of propargyl radicals, different reaction types, and asymmetric catalytic transformations.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500302

Authors: Bi‐Yin Xiao, Wei Huang, Feng‐Hua Zhang

Institutions: Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai Institute of Materia Medica, State Key Laboratory of Drug Research

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, University of Chinese Academy of Sciences, National Key Research and Development Program of China

Awards: G2353187143, G8270061139, G8595148300