Work

Oleanane-type triterpenoids from Sabia limoniacea with nitric oxide inhibitory activity

Year: 2025

Type: article

Abstract: Fourtheen undescribed oleanane-type triterpenoids (Sabialimons S-Z 6 ), including five nortriterpenoids ( 1 − 5 ) and nine normal triterpenoids ( 6 − 14 ), along with five previously described analogs ( 15 − 19 ) were isolated and characterized from the stems of Sabia limoniacea. Their structures were fully elucidated via extensive spectroscopic analyses , including 1D and 2D NMR , HRESIMS. Compounds 1 − 3 are oleanane-type triterpenoids which the rings A are broken and the carbons of position 2 are absent to form the five-membered ring-A contracted nortriterpenoids, resulting in the establishment of a 5/6/6/6/6 pentacyclic skeleton. Compounds 4 and 5 represent the interesting variation in which the C-1/C-3 bonds have been oxidatively cleaved to generate ring-A- seco triterpenoids , leading to establishment of a 0/6/6/6/6 tetracyclic skeleton. Biological evaluation revealed that compounds 9 and 10 can inhibited nitric oxide production in lipopolysaccharide stimulated RAW264.7 cells with IC 50 values of 36.40 and 36.52 μM, respectively.

Source: Phytochemistry

DOI: 10.1016/j.phytochem.2025.114497