An Innovative Phyto-mediated Nanocomposite-modified Glass Ionomer Cement: A Detailed Study on Synthesis, Cytotoxicity, Anti-inflammatory Effects, Antimicrobial Activity, Mechanical Performance, and Solubility
Year: 2025
Type: article
Abstract: Background: Glass ionomer cement (GIC), or polyalkenoate cement, is popular for esthetic restorations due to its tooth-bonding ability but suffers from low mechanical strength, abrasion resistance, and moisture sensitivity, leading to the search for better alternatives. Aim: To evaluate the cytotoxicity, anti-inflammatory, antimicrobial, mechanical properties, and solubility of phyto-mediated nanocomposite-modified GIC. Materials and methods: test. Results: < 0.05). Toxicological analysis showed no significant toxicity, and anti-inflammatory properties were stable. The modified GIC with phyto-mediated nanocomposite shows potential as a dental restorative material, especially in regions of high stress. Conclusion: Our findings indicate that 10% phyto-mediated Ch-Ti-Zr-HA nanocomposite-modified GIC excels in antibacterial activity, compressive and flexural strength, microhardness, and solubility, outperforming conventional GIC and showing potential for enhanced dental applications. How to cite this article: An Innovative Phyto-mediated Nanocomposite-modified Glass Ionomer Cement: A Detailed Study on Synthesis, Cytotoxicity, Anti-inflammatory Effects, Antimicrobial Activity, Mechanical Performance, and Solubility. Int J Clin Pediatr Dent 2025;18(2):181-190.
Authors: Aleena Alex, Jessy Paulraj, Subhabrata Maiti, Rajeshkumar Shanmugam
Institution: Saveetha University
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409177498