IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis (Adv. Sci. 13/2025)
Year: 2025
Type: article
Abstract: Insulin-Regulated Aminopeptidase In septic platelets, insulin-regulated aminopeptidase (IRAP) adsorbs ribosomal proteins and cooperates with autophagosomal proteins to promote lysosomal degradation of r-proteins, thereby providing amino acids required for durative glycolysis, which ensures mitochondrial function and finally provides abundant ATP for prolonged platelet activation. In addition, IRAP is also involved in SNARE complex assembly to facilitate granules release. More details can be found in article number 2411914 by Jinghong Zhao, Junping Wang, Shilei Chen, and co-workers.
Source: Advanced Science
Authors: Baichuan Xu, Xianpeng Ye, Kangfu Sun, Liang Chen, Zhaoyang Wen, Qigang Lan, Jun Chen, Mo Chen, Mingqiang Shen, Song Wang, Yang Xu, Xi Zhang, Jinghong Zhao, Junping Wang, Shilei Chen
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W4409178056