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Regioselective Synthesis of 5‐(1,2,3‐Triazol‐1‐yl)isoxazoles by Cyclization of 5‐Azidoisoxazoles with Active Methylene Compounds

Year: 2025

Type: article

Abstract: A facile metal‐free approach to 5‐(1,2,3‐triazol‐1‐yl)isoxazoles bearing a variety of functional groups in both heterocyles has been developed. A cyclization of 3‐EWG‐5‐azidoisoxazoles with compounds possessing active methylene group proceeds smoothly under mild conditions in the presence of triethylamine or Cs 2 CO 3 in alcohols or DMF affording fused hybrid triazole‐isoxazole compounds in high yields up to 98%. Some mechanistic aspects of the cyclization reaction are discussed.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202500086

Authors: Sevastian E. Dronov, Dmitry A. Vasilenko, Yuri K. Grishin, Victor A. Tafeenko, Elena B. Averina

Institution: Lomonosov Moscow State University

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Lomonosov Moscow State University

OpenAlex ID: W4409178614

FWCI: 0.298

Cites: 69

Cited by: 1

Related to: 10