NHC‐Catalyzed Asymmetric Intramolecular [3+2] Annulations of Cyclohexadienone‐Tethered Ynals
Year: 2025
Type: article
Abstract: NHC‐Catalyzed enantioselective conversion of ynals remains challenging through nucleophilic NHC‐allenolate intermediates. Herein, we present an NHC‐catalyzed highly asymmetric intramolecular [3+2] annulation of cyclohexadienone‐tethered ynals. This reaction enables a rapid and efficient construction of 6,5,5‐tricyclic frameworks bearing three contiguous stereocenters in excellent enantioselectivities. Additionally, the synthetic utility is elaborated through a gram‐scale experiment and several downstream transformations.
Authors: Ya‐Jie Wang, Ya‐Jie Wang, Wen‐Yu Kang, Wen Xu, Yu‐Hui Wang, Yu‐Hui Wang, Ping Tian
Institution: Shanghai University of Traditional Chinese Medicine
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4409178776