Work

Self-assembly supramolecular ternary co-crystal systems containing Glibenclamide: physicochemical and Pharmacodynamic studies

Year: 2025

Type: article

Abstract: The bioavailability of the drug is affected to a great extent by drug solubility . Most of the available and developed drugs are classified as poorly water-soluble drugs. The aim of this work is to formulate a ternary co-crystal matrix of Glibenclamide (GB) with the aid of Nicotinic acid (NA) as coformer and Brij-35 as surfactant, to enhance the solubility of the drug. Based on a statistical design at a level of 3 2 , nine different matrices were prepared and characterized for their flow properties and in vitro dissolution rate. Although the dissolution rate of all formulations was better than that of pure drug, the flowability of the powder is very important. The optimized formula, which is composed of 2.81 NA and 0.5 Brij-25, has good flowability in terms of Carr's index of 18.9 % and enhancement in the dissolution rate by 1.4-fold. In addition, the XRPD for the optimized formula shows a new peak that does not appear in the physical mixture. This may indicate the formation of new compounds that have better dissolution rates. The pharmacodynamics of the optimized matrix was tested against the pure drug, and it showed a significant reduction in fasting blood glucose level (P = 0.01).

Source: Journal of Drug Delivery Science and Technology

DOI: 10.1016/j.jddst.2025.106875

Authors: Doaa H. Alshora, Mohamed A. Ibrahim, Ranim F. Alshahrani, Ahlam Alhusaini, Nawal Alanaze, Abdullah Ahmed Alghannam

Institution: King Saud University

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,810