Work

Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis

Year: 2025

Type: article

Abstract: Mediastinal liposarcoma are rare occurrences of liposarcomas, arising from mesenchymal fat cells. They have several histological subtypes including well-differentiated, dedifferentiated, myxoid and pleomorphic. They often present with nonspecific symptoms of mass effect on nearby structures. Surgical resection is the mainstay of treatment, but high recurrence rate remains a challenge. We present the case of a 70-year-old male with a large dedifferentiated anterior mediastinal liposarcoma presenting with compressive symptoms. Coordinated efforts from radiology, histopathology and surgical teams are required for timely and accurate diagnosis and an optimized course of treatment.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.03.035

Authors: Charles K. Crawford, Hajra Arshad, Elliot K. Fishman

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600