Work

Therapeutic Glypican‐3 CRISPR Genome‐Editing Using UltraLarge Porous Silica Nano‐Depot for the Treatment of Hepatocellular Carcinoma

Year: 2025

Type: article

Abstract: CRISPR Gene Editing Ultra-large porous silica nano-depot (UPSND) enables the efficient delivery of large CRISPR-Cas9 proteins and sgRNA cassettes to target Glypican 3 in hepatocellular carcinoma cells. This genome editing strategy achieves significant tumor regression and prevents proliferation, while GPC3 deletion enhances immune cell infiltration into tumor tissues, indicating its potential for cancer immunotherapy. More in article number 2400447, Hyojin Lee, Seongchan Kim, Dong-Hyun Kim, and co-workers.

Source: Small Science

DOI: 10.1002/smsc.202570013

Authors: Sanghee Lee, Sian Lee, Hyojin Lee, Seongchan Kim, Dong‐Hyun Kim

Institutions: Northwestern University, Korea University, Korea Institute of Science and Technology, Gyeongsang National University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,350