Work

Drug-Induced Thrombotic Microangiopathy Arising During the Treatment of Anal Carcinoma After the Use of Mitomycin C

Year: 2025

Type: article

Abstract: Anal cancer is a rare disease where malignant cells originate in the tissues of the anal canal. This form of cancer is classically treated with a combination of radiation therapy and a chemotherapy regimen that includes mitomycin C. This case illustrates an unusual presentation of thrombotic microangiopathy associated with mitomycin C. A 57-year-old woman with a history of anal carcinoma treated with capecitabine/mitomycin C and radiation was sent to the emergency department by her oncologist for an incidental finding of worsening kidney function noted on a complete metabolic panel done prior to getting radiographic imaging. The patient was admitted to the hospital for suspected acute kidney injury from suspected ureteral obstruction and stent occlusion; however, despite reversal of the stents, renal function did not improve. Renal biopsy confirmed thrombotic microangiopathy and diagnosis of drug-induced thrombotic microangiopathy. This case discusses a side effect of thrombotic microangiopathy from mitomycin C and successful treatment with eculizumab.

Source: Cureus

DOI: 10.7759/cureus.81731

Authors: Krishna Sheth, Cody Lee, Mihir Patel, Hannah Mathew, Ajith Saju, Sergio Obligado

Institutions: Touro College, The University of Texas Southwestern Medical Center

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409197630