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Toxic Epidermal Necrolysis-Like Acute Cutaneous Lupus Erythematosus Following an Upper Respiratory Infection

Year: 2025

Type: article

Abstract: Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus (TEN-like ACLE) is a rare and severe form of cutaneous lupus erythematosus with an unclear etiology. We present a case of a 49-year-old woman with a past medical history of systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's overlap syndrome who developed TEN-like ACLE following a week-long upper respiratory infection (URI). While there are reported cases of TEN-like ACLE associated with excessive ultraviolet light exposure and abrupt medication discontinuation, this case uniquely highlights the novel association between URI and TEN-like ACLE, suggesting that URI may act as a previously unrecognized environmental trigger and precipitating agent for this rare condition.

Source: Cureus

DOI: 10.7759/cureus.81798

Authors: Matthew J Yan, Huy Phan, Sherwin Hsu, Yuna Kang, Yang Yu

Institutions: University of California, Los Angeles, Los Angeles Medical Center, Olive View-UCLA Medical Center

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409199676