Work

Microwave-Based Label-Free Immunosensor to Detect Anti-P53 Autoantibodies

Year: 2025

Type: article

Abstract: A microwave-based label-free biosensor was designed and tested to detect anti-p53 antibodies, an early detection biomarker of cancer. The biosensor utilized a$50-\Omega$microstrip line with stepped impedance resonators (SIRs) optimized to resonate at 5.25 GHz. Experimental evaluations showed that the biosensor could detect binding events with a linear response from 10 up to$1250 \text{pg} / \text{mL}$, a sensitivity of 0.104$\text{MHz} \cdot \text{mL} / \text{pg}$, and a limit of detection (LOD) of$\mathbf{3 1 5. 7 ~ p g} / \mathbf{m L}$. The biosensor demonstrated effective biomolecule detection, paving the way toward affordable early cancer biomarker detection.

Source: Sensors and Actuators B Chemical

DOI: 10.1016/j.snb.2025.137702

Authors: Sebastian Montoya-Villada, Jahir Orozco, Erick Reyes-Vera

Institutions: Institución Universitaria ITM, Universidad de Antioquia

Language: English

Topic: Microwave and Dielectric Measurement Techniques

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,010