Work

Case Report of Dermatomyositis With Features of the Wong Variant Developing Post‐Trastuzumab Therapy for Breast Cancer

Year: 2025

Type: article

Abstract: Drug-induced dermatomyositis can be challenging to distinguish from paraneoplastic dermatomyositis. Rarely, antibodies directed against human epidermal growth factor receptor 2 (HER-2), such as trastuzumab, may trigger dermatomyositis, and immune checkpoint inhibitors may incite the Wong variant of dermatomyositis, characterised by clinical and histopathologic features of pityriasis rubra pilaris, including monomorphic keratotic papules. We present an unusual case of dermatomyositis with features of the Wong variant occurring in a 51-year-old female with a history of breast cancer after completion of adjuvant therapy with trastuzumab.

Source: Australasian Journal of Dermatology

DOI: 10.1111/ajd.14456

Authors: Lauren C. LaMonica, Margaret E. Lang Houser, Paul W. Harms, Frank Wang

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,160