Work

Plasmapheresis for Facilitating Readministration of Rituximab After Paradoxical Exacerbation in Pemphigus Vulgaris: A Case Report

Year: 2025

Type: article

Abstract: Rare reports of post-rituximab exacerbation of pemphigus vulgaris (PV) have been published, with some therapeutic protocols proposed for managing this condition. A 40-year-old female with PV experienced an exacerbation of mucocutaneous lesions following rituximab administration. She failed to respond to conventional immunosuppressive agents, intravenous immunoglobulin, and ocrelizumab, so plasmapheresis was administered. Then, further doses of rituximab were prescribed, and mucocutaneous lesions improved significantly. We propose plasmapheresis as a possible treatment for post-rituximab PV exacerbation, also noting that subsequent doses of rituximab can be safe and effective.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.70375

Authors: Mohammad Reza Pourani, Sayyed Mojtaba Nekooghadam, Fatemeh Samadi, Sanaz Soleimani, Fahimeh Abdollahimajd

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820