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Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN

Year: 2025

Type: article

Abstract: BACKGROUND: Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. METHODS: Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. RESULTS: Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways. CONCLUSIONS: Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.

Source: Journal of Diabetes

DOI: 10.1111/1753-0407.70068

Authors: Jinzhou Liu, Min Guo, Xiaobin Yuan, Xiao Fan, Jin Wang, Xiangying Jiao

Institutions: Shanxi Medical University, First Hospital of Shanxi Medical University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000