Work

Microimager: a flexible thin-film miniaturized endoscope for optical biomedical imaging

Year: 2025

Type: article

Abstract: Optical imaging is the gold standard for visualizing the structure and function of biological tissue. Non-invasive imaging methods can only reach a limited depth while providing a high spatial resolution. On the other hand, implantable imagers that can access deep tissue are prohibitively large and invasive. Here, we present the Microimager, a flexible, miniaturized thin-film endoscope (7 × 400 μm) featuring multiple independent channels for high-resolution light delivery and collection from deep tissue. The Microimager consists of an array of parylene photonic waveguides implemented using a scalable microfabrication process. We experimentally demonstrate spatial discrimination and imaging of 30 µm features on a resolution mask, as well as distinct regions in mouse brain tissue. The Microimager is a useful addition to the optical biomedical imaging toolset and can provide access to deep tissue in a minimally invasive way for a wide range of applications.

Source: Biomedical Optics Express

DOI: 10.1364/boe.558778

Authors: Mohammad Hassan Malekoshoaraie, Vishal Jain, Kanika Sarna, Jay W. Reddy, Maysamreza Chamanzar

Institution: Carnegie Mellon University

Language: English

Topic: Random lasers and scattering media

Subfield: Acoustics and Ultrasonics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,913

Funder: National Science Foundation