Work

Utilizing an attritor mill for solvent-free mechanochemical synthesis of rac -ibuprofen:nicotinamide co-crystals

Year: 2025

Type: article

Abstract: The study demonstrates the efficient, solvent-free mechanochemical synthesis of rac -ibuprofen:nicotinamide co-crystals using an attritor mill, achieving a 99% yield of high-purity co-crystals in 30 min.

Source: RSC Mechanochemistry

DOI: 10.1039/d5mr00020c

Authors: Sarah Triller, Frederik Winkelmann, Jan-Hendrik Schöbel, Michael Felderhoff

Institution: Max-Planck-Institut für Kohlenforschung

Language: English

Topic: Crystallography and molecular interactions

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: European Commission, HORIZON EUROPE Framework Programme

Awards: Innovative Mechanochemical Processes to synthesize green ACTIVE pharmaceutical ingredients., G4827025924

OpenAlex ID: W4409207413

FWCI: 0.902

Cites: 45

Cited by: 2

Related to: 10