Comparative Study of Functional Outcome of Intra-articular Injection of Platelet-Rich Plasma versus Corticosteroid in Treatment of Osteoarthritis of Knee
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Introduction: The entire joint structure is impacted by osteoarthritis (OA). The hands, knees, and hips are the joints that sustain the greatest injuries. Since OA is a prevalent illness worldwide and a leading cause of impairment in the elderly, doctors are constantly searching for efficient treatments to reduce pain and enhance symptoms so that patients can live better lives. Materials and Methods: This prospective randomized controlled study was conducted at the orthopedics outpatient department at Chettinad Hospital and Research Institute, Kelambakkam. A total of 40 patients were enrolled in the study. WOMAC and LEQUESNE index scores were deployed to evaluate the functional outcomes of patients at baseline, 1st, 3rd, and 6th months. Results: The mean age of the study participants was 54.69 ± 2.15 and the majority of them belong to more than 50-60 years old, which is 16 (40%) participants. The mean WOMAC index scoring had a significant difference, with the P-value being significant (P < 0.05) measuring at 1st month, 3rd months, and during 6th months as 0.011, 0.026, and 0.002, respectively. The mean LEQUESNE index scoring had significant differences, with the P-value being highly significant (P < 0.005) for the 1st month, 3rd month, and during 6th months (P < 0.005). Conclusion: Intra-articular platelet-rich plasma injection is considered safe, found to be more potential in alleviating pain and joint stiffness, and also provides better functional outcomes of the knee joint in patients with OA when compared to intra-articular corticosteroids.
Authors: Amal Shaji, E Pradeep, K V Arun Kumar, S Dinesh Kumar, Sheik Mohideen, V Y Ashwin
Institution: Chettinad Academy of Research and Education
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $250
OpenAlex ID: W4409212614