Work

Immunogenicity assessment of a swine fever-swine circovirus type 2 duplex vaccine candidate created using the Zera nanoparticle delivery method

Year: 2025

Type: article

Abstract: Classical swine fever virus (CSFV) and porcine circovirus (PCV) are the primary pathogens of swine fever and pig circovirus infections, respectively. Co-infections with these diseases result in severe economic losses for the swine sector. To prevent and control the disease, immunization is the primary technique for reducing co-infections and economic losses. In this work, we created a new nanoparticle vaccine using a Zera nanoparticle delivery system that expressed swine fever virus E0 and E2 proteins as well as porcine circovirus Cap proteins. We then inoculated BALB/c mice to test the vaccine's immunogenicity. The findings revealed that this nanoparticle vaccine could stimulate the mouse organism to produce high levels of humoral and cellular immunity, making it a promising candidate for the development of subunit vaccines against swine fever and swine circulatory-associated diseases. This study also provides ideas for other disease vaccines.

Source: Veterinary Immunology and Immunopathology

DOI: 10.1016/j.vetimm.2025.110929