Work

Talarodride I, an Unusual Penta‐Nor‐Nonadride and Other Derivatives Characterized From the Deep‐Sea Seamount‐sourced Endozoic Talaromyces scorteus AS‐242

Year: 2025

Type: article

Abstract: Talarodride I (1), the first representative of penta-nor-nonadride derivative having a caged bicyclo[4.3.1]deca-2,6-diene core skeleton with an aldehyde group at C-15, together with a new congener talarodride J (2) and five known secondary metabolites (3-7), were isolated and identified from the Magellan seamount-sourced sea-anemone endozoic fungus Talaromyces scorteus AS-242. Their structures were assigned by nuclear magnetic resonance and mass spectroscopic data analysis and time-dependent density functional theory electronic circular dichroism calculations. In the antibacterial assays compounds 1-5 displayed activities against a broad spectrum of human- and aquatic pathogens, with compounds 1 and 2 showing potent inhibitory effects against Escherichia coli and Aeromonas hydrophilia (minimum inhibitory concentration values 1-4 µg/mL).

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202500726

Authors: Guan‐Hai Dong, Xiao‐Ming Li, Ying Wang, Bin‐Gui Wang, Ling‐Hong Meng

Institutions: Chinese Academy of Sciences, Institute of Oceanology, Qingdao National Laboratory for Marine Science and Technology, University of Chinese Academy of Sciences

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Awards: G1167625638, G3368581203