Work

Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4 H )‐Ones to Aurone‐Derived Azadienes

Year: 2025

Type: article

Abstract: An efficient enantioselective organocatalytic conjugate addition of isoxazol‐5(4 H )‐ones to aurone‐derived azadienes under mild conditions has been developed. This methodology provides access to a wide range of chiral compounds featuring both benzofuran and isoxazole scaffolds in their structures achieving high yields and stereo control. Furthermore, the resulting adducts can be readily transformed into chiral β‐benzofuran‐branched carbonyl compounds in high yields and enantioselectivity in one‐pot reaction through hydrolysis‐decarboxylation of the isoxazole ring.

Source: ChemCatChem

DOI: 10.1002/cctc.202500033

Authors: Ricardo Torán, Jordi Torró, Amparo Sanz‐Marco, Carlos Vila, Gonzalo Blay

Institution: Universitat de València

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Universitat de València, Agencia Estatal de Investigación, Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana