Work

An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics

Year: 2025

Type: article

Abstract: The mechanism of atherosclerosis lesions was investigated based on a fluid–structure interaction method according to the geometric reconstruction of human arteries by medical imaging. Numerical simulation, mechanical analysis, and dynamic simulation were used to establish a model of the mechanical characteristics of arterial blood transport, analyze the fluid properties of arterial blood flow under the influence of vascular lesion process, and study the mechanism of arterial lesion formation and development. The results indicated that the clinically important areas of secondary flow were generated at stenosis and bifurcation sites, which were prone to lesions during a cardiac cycle. The low flow rate and shear stress levels of blood in this region led to the adhesion and precipitation of lesion-inducing factors on the intimal tissue, creating a hydrodynamic environment suitable for lesion development. According to the research reported here in, early clinical detection and follow-up of atherosclerosis can be performed by collecting data on wall shear stress and blood flow pressure difference.

Source: Applied Sciences

DOI: 10.3390/app15074055

Authors: Lei Guo, Ye Lu, Shusheng Zhang

Institutions: Huaihua University, Shandong University

Language: English

Topic: Elasticity and Material Modeling

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896