Why and How to Improve Nutritional Care for Pregnant Women after Bariatric Surgery: The NUMASURG Study Protocol
Year: 2025
Type: article
Study design: Study Protocol
Abstract: Introduction: Pregnancies after bariatric surgery (BS) are considered at risk because of increased rate of maternal micronutrient deficiencies, small for gestational age, and prematurity. Longer-term data on child health are scarce and conflicting. The objective of the NUMASURG project is to understand the consequences of micronutrient deficiencies during pregnancy after BS for the mother and the offspring and to better document the child's health outcomes after maternal BS. Methods: NUMASURG is a collaborative project bringing together clinicians, biologists, epidemiologists, clinical researchers, and the French Obesity Research Center of Excellence network. The project is organized into four specific tasks: (1) establish a cohort of 1,000 pregnant women with a history of BS; (2) establish reference values for nutritional biomarkers during pregnancy (vitamins A, B9, B12, 25[OH]-D, zinc, ferritin) from two birth cohorts of the French general population (EDEN and ELFE); (3) compare the nutritional status between pregnant women after BS and women from the general population and investigate the associations between nutritional biomarkers and small for gestational age and prematurity in both populations; and (4) describe the health of children born from mothers with a history of BS using the French national health data system. Started in September 2023, the project will run for 4 years. Conclusion: The NUMASURG project will allow for implementing updated recommendations concerning the monitoring and nutritional supplementation of pregnant women with a history of BS. Ultimate objective are to improve the nutritional status of these women and consequently limit the main risks currently observed during pregnancy after BS. Structuring a clinical database will help standardize practices and enable future research projects in this area and will be a key first step in creating a prospective cohort of children born from mothers with a history of BS. .
Source: Obesity Facts
DOI: 10.1159/000545123
Authors: Cécile Ciangura, Claire Rives-Lange, Bénédicte Lelièvre, Martine Laville, Marie-Aline Charles, Bérénice Ségrestin, Barbara Heude, On behalf of the NUMASURG Study Group
Institutions: Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institut national de recherche en sciences et technologies du numérique, Inserm, Université Paris Cité, Hôpital Européen Georges-Pompidou, Heka : Méthodes basées sur les données et modèles en santé pour l'acquisition de connaissances, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Lyon 1 Université, Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, Institut national d'études démographiques, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Sorbonne Paris Nord, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche Épidémiologie et Statistique, Etude longitudinale française depuis l'enfance, Hospices Civils de Lyon
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,590
Funders: European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Socialdepartementet, Université Paris-Sud, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Mutuelle Générale de l'Education Nationale, Etablissement Français du Sang, Institut pour la Recherche en Santé Publique, CHIST-ERA
OpenAlex ID: W4409234061