Work

Enzyme-free optical detection of uric acid using corona phase molecular recognition in near-infrared fluorescent single-walled carbon nanotubes

Year: 2025

Type: article

Abstract: /SWCNT and further optimized it with studying the pH effects to account for the natural pH variation in urine. To facilitate point-of-care (POC) application, we integrated the corona nanosensor with an optical paper strip, achieving a rapid and intense turn-on NIR response up to 4 times stronger when exposed to urine samples containing UA concentrations ranging from 5.7 to 500 μM. Moreover, the corona nanosensor-integrated paper strip exhibited reliable performance even under harsh conditions of 70% relative humidity and 40 °C. This study demonstrates the enzyme-free UA detection capability of SWCNT-based CoPhMoRe in complex biofluids, establishing its potential for future application as an optical test strip in POC diagnostics.

Source: Nanoscale

DOI: 10.1039/d4nr05046k

Authors: Minyeong Yoon, Seyoung Shin, Seungju Lee, Soo-Yeon Cho

Institution: Sungkyunkwan University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Research Foundation, Korea Health Industry Development Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea

Awards: G2198112615, G2582708709, G3300669116, G4332777198, G7240127599