Work

Comprehensive review of the vascular niche in regulating liver regeneration, fibrosis, and hepatocellular carcinoma

Year: 2025

Type: article

Abstract: The liver serves as a crucial regulatory center in the human body, orchestrating various essential physiological processes and maintaining homeostasis . This organ is heterogeneous, consisting of hepatocytes, liver sinusoidal endothelial cells , hepatic stellate cells , and Kupffer cells . These cells are intricately linked in structure and communicate via autocrine and paracrine signaling , playing key roles in the regulation of liver regeneration and fibrosis following injury . In this review, we provide a brief overview of the different cell types within the vascular niche. Moreover, we discuss some of the molecular mechanisms within this niche that guide liver regeneration and fibrosis, as well as hepatocellular carcinoma . It is important to highlight that developing new treatments for liver diseases necessitates a comprehensive understanding of these cellular and molecular mechanisms.

Source: EngMedicine

DOI: 10.1016/j.engmed.2025.100070

Authors: Yutian Chen, Yangfan Zhou, Peipei Li, Bi-Sen Ding

Institutions: First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Sichuan University, West China Second University Hospital of Sichuan University, State Key Laboratory of Biotherapy

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,300