Scleromitrion diffusum reverses epithelial-mesenchymal transi-tion of gastric mucosa in rats with gastric precancerous lesions
Year: 2025
Type: article
Abstract: Objective To investigate the effect of Scleromitrion diffusum on gastric mucosal epithelial mesenchymal transformation (EMT) in rats with gastric precancerous lesion. Methods 50 SD rats were randomly divided into blank control group (n=11), model control group (n=13), Scleromitrion diffusum (SD) group (n=13) and vitase group (n=13). Gastric precancerous lesion animal model was prepared by 1-methyl-3-nitro-1-nitroso guanidine complex polyfactor method, and the drugs were administrated by gavage after successful modeling once a day for 6 weeks. The pathological changes of gastric mucosa were observed with hematoxylin-eosin staining, the expression of EMT marker proteins were detected with immunohistochemical staining and Western blotting. Results Compared with the model control group, the gastric mucosal injury was significantly attenuated in the SD group, the mucosal tissue structure gradually recovered, the saccular expansion area was reduced, and the inflammatory infiltration was ameliorated. The expression level of epithelial cadherin was higher, and the expression levels of neural cadherin and vimentin were lower than those of model control group (all P<0.05). Conclusion Scleromitrion diffusum can ameliorate gastric mucosal injury in rats with gastric precancerous lesion by reversing epithelial mesenchymal transformation.
Authors: Luping MA, Xin ZUO, Weikai ZHU, Jiyan LI, Yanyan ZHAO, Jingyuan ZHANG, Hui SHEN
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409238100