Year: 2025
Type: article
Abstract: Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.
Source: Chemical Communications
DOI: 10.1039/d5cc00550g
Institution: University of Groningen
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4409238302