Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: The aim of the present study is to assess the role of the level of change in gene expression of the HOTAIR molecule in breast cancer patients.Methods: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients and 10 healthy controls, by performing the reverse transcription reaction RT-qPCR, gene expression was evaluated using the Livak equation, tumor characteristics (grade, HER2 receptors, hormonal (HR) receptors) were also studied in the Pathological Anatomy Department and compared between patients.Results: The results of the study showed that there was a significant difference (P < 0.05) in the level of change in gene expression between the patients and controls.There was a correlation between the level of change in gene expression and tumor grade, positivity for HER2 receptors and negativity for HR receptors.Conclusion: It was found that the gene expression level of HOTAIR molecule may have a prognostic significance in the diagnosis of breast cancer and the characteristics of the tumor responsible for increasing tumor virulence and poor prognosis.
Source: OALib
Authors: Faisal Redwan, Nader Abdullaa, Eyad Alshatti, Ansam Abdullah
Institutions: Latakia University, Damascus University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409241260