Work

Disruption of the EmrAB-TolC efflux pump of Escherichia coli induces global metabolic changes in multiple growth conditions

Year: 2024

Type: article

Abstract: . Here, we investigated the contribution of EmrAB-TolC to metabolism in various conditions. Deletion of EmrB led to changes in several metabolic pathways, both in standard growth conditions and during nutrient stress. The pathways impacted include the tricarboxylic acid (TCA) cycle, and carbohydrate and amino acid metabolism. Our findings suggest that EmrAB-TolC contributes to maintaining metabolic homeostasis and adapts metabolism based on cellular needs.

Source: PubMed

DOI: 10.17912/micropub.biology.001437

Authors: Dana E. Harmon, Klay Adamson, Joseph Wiersma

Institution: California Lutheran University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4409241905

FWCI: 0.245

Cites:

Cited by: 1

Related to: 10