Work

Manganese-Catalyzed α-Trideuteromethylation of Sulfones

Year: 2025

Type: article

Abstract: Recent advancements in deuteration techniques have garnered significant attention from both academia and industry. Herein, we report a manganese-catalyzed α-trideuteromethylation of sulfones with CD3OD as a deuterating reagent via a deuterium autotransfer strategy under mild conditions. Our approach yields target compounds with 60–96% efficiency and deuteration levels up to 99%. This methodology stands out due to its reliance on accessible deuterium sources, an earth-abundant transition-metal catalyst, and mild conditions.

Source: Synlett

DOI: 10.1055/a-2577-4220

Authors: Weiping Liu, Guanbo Li

Institution: Donghua University

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities