Work

Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies

Year: 2025

Type: article

Abstract: and, by implication, other nucleophilic cysteine enzymes.

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2025.117603

Authors: Dóra Laczi, Sofia Schönbauer Huamán, Taylah Andrews-Clark, Stephen M. Laidlaw, Eidarus Salah, Leo Dumjahn, Petra Lukacik, Hani Choudhry, Martin A. Walsh, Miles W. Carroll, Christopher J. Schofield, Lennart Brewitz

Institutions: University of Oxford, Diamond Light Source, Research Complex at Harwell, Centre for Human Genetics, King Abdulaziz University

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Wellcome Trust, European Commission, King Abdulaziz University, U.S. Food and Drug Administration, Biotechnology and Biological Sciences Research Council

Awards: RapidFire Enhancement of Mass Spectrometry Capability Across the Biosciences, G3420693015, Defining the physiology and therapeutic potential of oxygenases as signalling enzymes., Evolution of Oxygen Sensing in Animals

OpenAlex ID: W4409252796

FWCI: 6.339

Cites: 125

Cited by: 9

Related to: 10