Work

Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with multiple sclerosis by mass cytometry and proteomics

Year: 2025

Type: article

Abstract: memory B cells only rarely repopulated. This repopulation was associated with a reduction of memory T cells and activated myeloid cells, as well as reduced expression of activation/migration markers in both cell types. A plasma proteomics analysis identified proteins including TNFRSF13C, associated with B cell depletion and repopulation. Plasma levels of neurofilament light-chain protein declined after ocrelizumab treatment was not linked with B cell repopulation. These findings identify potential soluble markers for monitoring of ocrelizumab treatment in MS.

Source: iScience

DOI: 10.1016/j.isci.2025.112383

Authors: Meng Wang, Carolin Otto, Camila Fernández Zapata, Adeline Dehlinger, Gerardina Gallaccio, Lisa-Marie Diekmann, Moritz Niederschweiberer, Patrick Schindler, Peter Körtvélyessy, Desiree Kunkel, Friedemann Paul, Klemens Ruprecht, Chotima Böttcher

Institutions: Max Delbrück Center, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Freie Universität Berlin

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Novartis, F. Hoffmann-La Roche, Guthy-Jackson Charitable Foundation, European Commission, Deutsche Forschungsgemeinschaft, National Natural Science Foundation of China, Bundesministerium für Bildung und Forschung, Government of Jiangsu Province, China Scholarship Council, Natural Science Foundation of Jiangsu Province, Stiftung Charité, Medical Research Council, National Medical Research Council

Awards: G1107410517, G1467412327, G3256625789, G4097063786, TRR 167: Entwicklung, Funktion und Potential von myeloiden Zellen im zentralen Nervensystem (NeuroMac), G8475855818, G8680196664

OpenAlex ID: W4409255444

FWCI: 4.116

Cites: 58

Cited by: 7

Related to: 10