Work

Is the acid load of the diet related to esophageal cancer? A case-control study

Year: 2025

Type: article

Abstract: Background Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established. Therefore, a study was conducted to investigate the association between DAL and EAC. Methods This case-control study involved 120 individuals with EAC as the case group and 240 individuals without a history of malignancy as the control group. Dietary intake was assessed using a valid food frequency questionnaire (FFQ), and the dietary acid load (DAL) was calculated using a valid formula. The association between DAL and EAC was evaluated using multivariate logistic regression analysis. Results The results of the current study indicate that, after adjusting for potential confounding factors, individuals with a higher potential renal acid load (PRAL) score in their diet have an elevated risk of developing EAC (OR: 2.3; 95%CI: 4.41–1.11; p:0.03). In contrast, there was no significant association between the net endogenous acid production (NEAP) index score and the risk of EAC (OR: 1.76; 95%CI: 0.9–3.24; p: 0.07). Conclusion The findings of the current study show that DAL has a direct and significant relationship with the risk of EAC.

Source: Clinical Nutrition Open Science

DOI: 10.1016/j.nutos.2025.03.011

Authors: Omid Nikpayam, Parmis Mirzaei, Golbon Sohrab, Amirmahdi Najafi, Reza Eghdam Zamiri, Alireza Ostadrahimi

Institutions: Golestan University of Medical Sciences, Shahid Beheshti University of Medical Sciences, Tabriz University of Medical Sciences

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200