Work

Asymmetric hydrogenation of α-pyrrolyl terminal alkenes: An easy access to enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center

Year: 2025

Type: article

Abstract: Herein we report a Rh-catalyzed asymmetric hydrogenation of α-pyrrolyl terminal alkenes to afford a series of enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center. The reaction features easy operation, mild conditions and excellent enantiocontrol (up to 99 % ee ). The products can be easily derivatized into diverse chiral pyrroles through facile transformations on the C5 position through the Friedel-Crafts reaction. Herein a highly efficient and enantioselective Rh-catalyzed asymmetric hydrogenation of α-pyrrolyl terminal alkenes is reported, providing a series of enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center with excellent enantiocontrol (up to 99 % ee ).

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2025.04.003

Authors: Ao Zhou, Nianxin Rong, Haokun Zhuang, Qin Yin

Institution: Shenzhen University of Advanced Technology

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Science, Technology and Innovation Commission of Shenzhen Municipality

Awards: G1945574692, G7526329185