Year: 2025
Type: article
Abstract: Biocatalytic cascades offer products of multistep synthesis without the use of protecting groups or isolation of intermediates. This strategy is particularly amenable to the synthesis of iminosugars, where traditional routes typically suffer from lengthy and inefficient steps. We have developed a one‐pot, three‐step biocatalytic cascade to synthesize trihydroxypiperidine and azepane iminosugars directly from monosaccharides, employing transaminase and galactose oxidase enzymes. An in situ LC/MS method for monitoring the key reaction intermediates that have never been observed was also developed.
Source: ChemCatChem
Institution: University College Dublin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funder: Research Ireland
OpenAlex ID: W4409256949