Efficient and Stereoselective Synthesis of (Z)‐2‐Oxazolines by Transition Metal‐Free Cycloisomerization of Internal Propargylic Amides in Hexafluoroisopropanol (HFIP)
Year: 2025
Type: article
Abstract: An efficient transition metal‐free protocol for the cyclization of propargylic amides with internal triple bonds to 2‐oxazolines is described. The reaction is performed in hexafluoroisopropanol (HFIP) in the presence of TMSCl which acts as a source of anhydrous HCl. The reaction conditions were optimized using response surface methodology. The oxazolines are formed stereoselectively with (Z)‐configuration of the exocyclic double bond.
Authors: Nicholas Jankowski, Norbert Krause
Institution: TU Dortmund University
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,030
OpenAlex ID: W4409258911