Foundation X: Integrating Classification, Localization, and Segmentation Through Lock-Release Pretraining Strategy for Chest X-Ray Analysis
Year: 2025
Type: conference-paper
Abstract: Developing robust and versatile deep-learning models is essential for enhancing diagnostic accuracy and guiding clinical interventions in medical imaging, but it requires a large amount of annotated data. The advancement of deep learning has facilitated the creation of numerous medical datasets with diverse expert-level annotations. Aggregating these datasets can maximize data utilization and address the inadequacy of labeled data. However, the heterogeneity of expert-level annotations across tasks such as classification, localization, and segmentation presents a significant challenge for learning from these datasets. To this end, we introduce Foundation X, an end-to-end framework that utilizes diverse expert-level annotations from numerous public datasets to train a foundation model capable of multiple tasks including classification, localization, and segmentation. To address the challenges of annotation and task heterogeneity, we propose a Lock-Release pretraining strategy to enhance the cyclic learning from multiple datasets, combined with the student-teacher learning paradigm, ensuring the model retains general knowledge for all tasks while preventing overfitting to any single task. To demonstrate the effectiveness of Foundation X, we trained a model using 11 chest X-ray datasets, covering annotations for classification, localization, and segmentation tasks. Our experimental results show that Foundation X achieves notable performance gains through extensive annotation utilization, excels in cross-dataset and cross-task learning, and further enhances performance in organ localization and segmentation tasks. All code and pretrained models are publicly accessible at GitHub.com/JLiangLab/Foundation_X.
Institutions: Arizona State University, Mayo Clinic
Language: English
Topic: COVID-19 diagnosis using AI
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4409263955