Get started
Work

Recent Advances in Mammalian Olfactory Receptor Function and Structure

Year: 2025
Type: article
Abstract: ABSTRACT Olfaction plays a fundamental role in survival and socialization of human beings, and its dysfunction not only includes deficits in smell but also contributes to the progression of various diseases. This review explores the role of mammalian olfactory receptors in odor perception and signaling within the olfactory system, their expression outside olfactory tissues, and recent structural discoveries. The involvement of olfactory receptors is investigated in diseases such as Alzheimer's and immune disorders, highlighting their potential as therapeutic targets. The olfactory activation mechanisms are summarized, offering a valuable reference for disease research and drug development targeting olfactory receptors, with the goal of advancing treatments for olfactory‐related diseases.
DOI: 10.1002/sen2.70000
Authors: Hongxi Qin, Yuerong He, Hong Fu, Kexin Wang, Yan Bin, Changling Xu, Fan Wu, Jiali Wei, Jiangang Fang, Wei Yan
Institutions: Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy, University of Electronic Science and Technology of China, Medical University of South Carolina, Hainan General Hospital, Hainan Medical University
Language: English
Subfield: Sensory Systems
Open Access status: diamond
OpenAlex ID: W4409272793
FWCI: 1.14
Cites: 106
Cited by: 2
Related to: 10