Year: 2025
Type: article
Abstract: Introduction: While Total Disc Replacements (TDRs) are generally performing well clinically, reoperation rates indicate that the full potential of the TDR concept might not have been reached. Inspired by the underlying complications related to biomechanics and material longevity that limit the performance of current TDRs, we propose a methodology for the development of TDR-bearings, that addresses such issues. Methods: Our methodology combines finite element model-based optimization with literature derived biomechanical data and an advanced ceramic material to design TDR-bearings. The design optimization aims to functionally replace the structures that are commonly excised (removed) or dissected (cut) during TDR implantation in the anterior column. Results: The optimized bearing geometry was able to replicate the moment-rotation curve of the anterior column of the natural C6/C7 level during coupled flexion/extension-anterior/posterior translation movement. Lateral bending and axial rotation were simulated to ensure the TDR would not fail during these load- and motion profiles. Experimental verification of the finite element model showed the suitability of our simulation approach. Discussion: The combination of computational techniques, advanced materials, and target biomechanical data may allow to overcome limitations of current TDRs and unlock the full potential of the TDR-concept.
Authors: Lucia Kölle, Markus Flohr, Gregory Pryce, Andrew R. Beadling, Michael Bryant, Richard M. Hall, Stephen J. Ferguson, Benedikt Helgason
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409276194