Work

Photochemical Homologated Aminophosphorylation of Carbon‐Carbon π ‐, and σ ‐Bonds Through Radical Translocation

Year: 2025

Type: article

Abstract: Difunctionalization of olefins serves as the workhorse for rapid creation of molecular complexity from simple feedstocks. However, these reactions are mostly restricted to the 1,2-variant, with higher homologations being attempted to a much lesser extent. Radical translocation strategies serve as an escape from the traditional 1,2-strategies, providing a means for achieving distant functionalizations that are otherwise difficult to access. Herein, we disclose visible light-mediated strategies for the accessing of 1,3-, 1,4-, 1,5-, and 1,6-aminophosphonates via combination of various radical shifting methods. In addition, the aminophosphorylation of σ-bonds was also achieved, leading to 1,3-aminophosphorylated cyclobutanes.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202500886

Authors: Apurba Samanta, Saradindu Debnath, Sudipta Maity, Sudipta Maity, Soumitra Maity, Soumitra Maity

Institution: Indian Institute of Technology Dhanbad

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Science and Engineering Research Board

Award: G479610684