Electrophilic glycoluril-based reagents for atom-economic thiocyanation and selenocyanation of (hetero)arenes

Year: 2025

Type: article

Abstract: -XCN reagents (X = S, Se) were developed for introducing SCN/SeCN groups into aromatic substrates, including the late-stage modification of bioactive molecules. Their application produces minimal waste, enables simple purification, and offers potential for reagent regeneration. Additionally, their compatibility with green solvents and flow technology was demonstrated. The sustainability of the process was evaluated using green metrics and Ecoscale values, emphasizing the complementary roles of the reagents and solvent recovery in enhancing atom economy and reducing waste.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00536a

Authors: Paula Casasús, Jordi Mestre, Roksana Radłowska, Miguel Bernús, Omar Boutureira

Institution: Universitat Rovira i Virgili

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Funders: Universitat Rovira i Virgili, European Regional Development Fund, Agencia Estatal de Investigación, European Social Fund

OpenAlex ID: W4409279447