Work

A Novel Formulation of Fosamprenavir Calcium: Therapeutic Deep Eutectic Solvent with Enhanced Properties

Year: 2025

Type: article

Abstract: In the pharmaceutical industry, deep eutectic solvents can be used to enhance the solubility, permeability, and absorption of active pharmaceutical ingredients. In this paper, deep eutectic solvents were prepared by combining the active pharmaceutical ingredient fosamprenavir calcium with lactic acid in certain molar ratios. The aim of this study was to create a therapeutic deep eutectic solvent with the same therapeutic effect as the active pharmaceutical ingredient, but with enhanced properties. 1H NMR and FTIR spectroscopy were used to identify and characterize the chemical composition and structural changes of the prepared THEDES. Maximum solubility, the release of the active pharmaceutical ingredient from the therapeutic deep eutectic solvent, and permeability were tested. Different mathematical models were chosen to describe the kinetic behavior of the drug release.

Source: Crystals

DOI: 10.3390/cryst15040350

Authors: Jasna Prlić Kardum, Iva Zokić, Aleksandra Sander, Patricija Pelin

Institution: University of Zagreb

Language: English

Topic: Ionic liquids properties and applications

Subfield: Catalysis

Field: Chemical Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,534